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Randomized controlled trials

  • Adjusting for baseline covariates in randomized controlled trials
  • Leveraging baseline covariates for improved efficiency in randomized controlled trials
  • Clustering in randomized controlled trials
  • Robustness to misspecification when adjusting for baseline in RCTs
  • Is the two sample t-test/ANOVA really biased in RCTs?
  • Improving efficiency in RCTs using propensity scores
  • Multiarm trials – should we allow for multiplicity?
  • Matching analysis to design: stratified randomization in trials
  • Estimands and assumptions in clinical trials
  • Confidence intervals for the hazard ratio in RCTs which agree with log rank test
  • Covariate adjustment and prediction of mean response in randomised trials
  • Live stream seminar 26th October 2017: Covariate adjustment and prediction of mean response in randomised trials
  • Randomisation as the basis for inference in trials
  • Comment on ‘Conditional estimation and inference to address observed covariate imbalance in randomized clinical trials’
  • ANCOVA in RCTs – model based standard errors are valid even under misspecification
  • Robustness of ANCOVA in randomised trials with unequal randomisation
  • The hazards of period specific and weighted hazard ratios
  • Is stratified randomisation in trials (at least large ones) pointless?
  • ‘An introduction to covariate adjustment in trials’ – PSI covariate adjustment event
  • On improving the efficiency of trials via linear adjustment for a prognostic score

Recent Posts

  • The role of post intercurrent event data in the estimation of hypothetical estimands in clinical trials
  • Multiple imputation for coarsened (grouped) factor covariates
  • What is meant by a ‘while on treatment’ estimand?
  • Does a Bernoulli/binomial model really assume everyone has the same probability p?
  • Multiple imputation with flexible parametric survival models
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