In a previous post we looked at the properties of the ordinary least squares linear regression estimator when the covariates, as well as the outcome, are considered as random variables. In this post we’ll look at the theory sandwich (sometimes called robust) variance estimator for linear regression. See this post for details on how to use the sandwich variance estimator in R.
The t-test and robustness to non-normality
The t-test is one of the most commonly used tests in statistics. The two-sample t-test allows us to test the null hypothesis that the population means of two groups are equal, based on samples from each of the two groups. In its simplest form, it assumes that in the population, the variable/quantity of interest X follows a normal distribution 
in the first group and is 
in the second group. That is, the variance is assumed to be the same in both groups, and the variable is normally distributed around the group mean. The null hypothesis is then that 
.
Linear regression with random regressors, part 2
Previously I wrote about how when linear regression is introduced and derived, it is almost always done assuming the covariates/regressors/independent variables are fixed quantities. As I wrote, in many studies such an assumption does not match reality, in that both the regressors and outcome in the regression are realised values of random variables. I showed that the usual ordinary least squares (OLS) estimators are unbiased with random covariates, and that the usual standard error estimator, derived assuming fixed covariates, is unbiased with random covariates. This gives us some understand of the behaviour of these estimators in the random covariate setting.